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Indeed, as mentioned above, hypoxia induced by vessel depletion can activate several mechanisms used by tumor cells to counteract the lack of oxygen and nutrients such as increased tumor invasiveness and co-option of normal vessels resulting in ineffective anti-angiogenic therapy

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The present study reveals that two mitochondria targeted agents, MitoQ and DPI were highly synergistic in reducing cell viability of MNA NB cells and MYCN-driven NB spheroids

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