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Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

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Despite individual variation, Xpd TTD/TTD mice were on average considerably more responsive to such stimuli after FOXO4-DRI treatment (Fig

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