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My understanding is that the goal of treatment during pregnancy is to prevent transmission to the new-born: once that goal is achieved, there may be limited benefit of ongoing treatment with respect to measurable differences in liver disease progression and cancer (because these generally occur later in life and many studies do not extend to the time when these occur)

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In the case of weight loss, a physician-supervised weight loss program will be the most effective way to lose weight and keep it off long-term