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Metabolic flux analysis utilizing 13 C labeled glutathione would yield additional information regarding flux of glutathione and glutamate under various conditions

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Therefore, specific treatments are required to remove these non-nutritive compounds

Biomarker-Guided Stratification as a Future tool NET-related biomarkersincluding citrullinated histone H3, MPODNA complexes, and cell-free dsDNAcould help identify high-NET phenotypes and inform therapy selection, though standardization and prospective clinical studies are still needed

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