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Tier 2 (promising but unproven): Cerebrolysin for optic neuroprotection based on multiple small human trials plus consistent animal data

Molina-Privado I, Rodriguez-Martinez M, Rebollo P, Martin-Perez D, Artiga MJ, Menarguez J, et al

It is anticipated that additional studies to clarify the precise role of E3 ligases in DKD will result in the development of novel medications that specifically target E3 ligases for the treatment of DKD

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J Biol Chem 279:891929 Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S (2001) Signal transduction events elicited by cancer prevention compounds