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It is found in saliva, urine, and various tissues and its concentrations in plasma decline with age

Therefore, the beneficial effects of ROS are achievable within physiological levels and deviation from redox window (as oxidative or reductive stresses) [29] will be associated with different pathologies including neurodegenerative diseases [30] diabetes [31] cardiovascular disease and atherosclerosis [32] rheumatoid arthritis [33] respiratory disease [34] carcinogenesis [35] ageing [36] female reproductive disease, pregnancy complications and recurrent pregnancy loss [37]

Among the GSDM family members, GSDMB, GSDMD, and GSDME have emerged as potential biomarkers for differentiating glioma grades [8]

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