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Excessive alcohol use carries significant short-term and long-term risks: Physical Health Risks Liver Disease : Heavy drinking is a common cause of liver inflammation (alcoholic hepatitis) and scarring (cirrhosis)

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Mechanistically, elevated lactate in mouse myocardial tissue and HUVECs triggers Snail1 lactylation, activating the TGF-/Smad2 signaling pathway and eventually promoting EndMT and cardiac dysfunction

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The effect is not forceful or synthetic