Previously reported changes in the abundance of this family Prevotellaceae in advanced PD seem to have been expanded upon by Bedarf and associates, who have shown a dramatic decrease in the numbers of Prevotella copri in patients with early-stage PD ( Prevotella produce SCFAs like butyrate, their decrease may affect intestinal barrier function and immune health and thus be involved in the pathogenesis of PD (Hey et al., 2023)
The evidence base is more mechanistic than clinical at this point
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