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The trial escalation tables stepped the amount up on a monthly cadence, beginning in the low single-digit milligram range and only advancing once the prior level felt comfortable

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Notably, non-internalized NPs like pristine SiO 2 NPs [452] and LaVO 4 :Eu 3+ NPs [459] can still trigger eryptosis, relying on Ca 2+ signaling, which can be mediated by their direct influence on Piezo1 channels