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This B12-IF complex reaches the terminal ileum, where it binds to heterodimeric receptors cubam composed of an outer protein cubulin and transmembrane protein amnionless , located on the surface of polarized epithelial enterocytes in the apical brush border ( In the bloodstream, free B12 may be bound by HC or transcobalamin (TC)

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Physical manifestations may include muscle weakness, sore tongue, shortness of breath, diarrhea, numbness, and difficulty walking

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