This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)
[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Woo H.D., Kim D.W., Hong Y.-S., Kim Y.-M., Seo J.-H., Choe B.M., Park J.H., Kang J.-W., Yoo J.-H., Chueh H.W., et al
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Factors such as genetics, lifestyle, and overall health play a significant role
doi: 10.18926/AMO/31854 130 XiaoJKhanMZMaYAlugongoGMMaJChenTet al