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The first 72-week non-diabetic obesity dose is 5 mg weekly. The lowest measured human trial dose is 1 mg weekly in type 2 diabetes. Is 2.5 mg tirzepatide therapeutic

Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics

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In addition to the lean and ob/ob mice, the study included 3-KO mice and WT controls obtained from genetically verified breeding colonies

Anti-inflammation NF-kB pathway inhibition and reduced pro-inflammatory mediator production in keratitis and colitis models