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A portion of the iron in the cytoplasm is transported to the mitochondria for the synthesis of heme and iron-sulfur clusters (ISCs) [72]

ROS are reactive forms of oxygen which include superoxide anion radical, hydrogen peroxide, singlet oxygen and hydroxyl radical, they are usually produced during normal metabolism of oxygen inside the mitochondria [116]

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This precise release mechanism ensures timely and targeted delivery of the drug, thereby enhancing its concentration at the specific site of the lesion (Xiao et al., 2021)