In addition to these soluble factors, MSCs also release Exos, which are extracellular vesicles (EVs) that carry functional molecules such as messenger RNAs (mRNAs), microRNAs (miRNAs), peptides, proteins, cytokines, and lipids to recipient cells [47,48,49]
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This allows the formation of native disulphide bonds in the ER through a complex process involving not only disulphide-bond formation, but also the isomerization of non-native disulphide bonds