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Shank, R.P

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GSH may rapidly oxidize to glutathione disulfide (GSSG) under oxidative stress, but under normal conditions, it is reduced back to GSH by glutathione reductase (GR) via an reductant nicotinamide ademine dinucleotidephosphate (NADPH) -dependent mechanism both in the cytosol and mitochondria to maintain the GSH/GSSG balance [6]

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