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In comparison, it only takes 60 man-hours today using modern equipment, chemicals, and techniques

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Abbreviations AR: Androgen receptor CS: Cigarette smoke ECARs: Extracellular acidification rates EGFR: Epidermal growth factor receptor GEO: Gene expression omnibus HIF-1: Hypoxia-inducible factor 1 HPAEC: Human pulmonary artery endothelial cell IGF-1: Insulin-like growth factor-1 IPA: Ingenuity pathway analysis M-CSF: Macrophage colony-stimulating factor MMP-2: Matrix metalloproteinase-2 MMP-9: Matrix metalloproteinase-9 NT-4: Neurotrophin-4 OCR: Oxygen consumption rates PDGF-AA: Platelet-derived growth factor-AA SA--Gal: Senescence-associated -galactosidase TGF3: Transforming growth factor 3 VEGFR3: Vascular endothelial growth factor receptor 3 2-DG: 2-Deoxyglucose References Borgerding M, Klus H

Because of this, light cigarettes can still deliver nicotine and contribute to addiction