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A 2019 study in Antioxidants (N=88) reported that erythrocyte glutathione levels were roughly 30% lower in adults with poorly controlled type 2 diabetes compared with healthy age-matched subjects

Dragsted LO, Pedersen A, Hermetter A, Basu S, Hansen M, Haren GR, Kall M, Breinholt V, Castenmiller JJ, Stagsted J, et al: The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers

Consequently, a deficiency in C4B protein in patients may impair its ability to bind microbial antigens

Natural peptide antibiotics of human neutrophils