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Diabetes 59(4):10301037 Calzetta L, Matera MG, Cazzola M (2018) Pharmacological mechanisms leading to synergy in fixed-dose dual bronchodilator therapy

Endo, A., Maeno, S., & Liu, S

Metabolism 68:2633

When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure