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Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits -glutamylcysteine synthetas (-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc system) [126, 127]

Detoxification: It aids in the elimination of toxins from the liver and other organs

Prevalence of high DNA fragmentation index in male partners of unexplained infertile couples

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The Treated group received a 5-day oral treatment course of 100 mg/kg phenformin (once daily for 5 days, D-2 to D2), whereas the Vehicle group received sterile water