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Differences between the GLP1 receptor agonists and brain penetrance as well as heterogenous response to these drugs may account for the inconsistency of clinical outcomes in PD [189]

It is not a replacement for prescribed mental health treatment, and severe depression should always be managed by a licensed clinician

Statements Author contributions KK: Conceptualization, Data curation, Formal Analysis, Writing original draft

This oxidative stress promotes atherosclerotic lesions and injures biliary epithelial cells (BECs) and TJ proteins via low-density lipoprotein oxidation enhanced by ROS activity (Kousik et al., 2012)

The extracellular subunit (130 KDa) is sialylated via 2, 6-linkages and binds the IGF-1R ligands (IGF-1, IGF-2), while the intracellular subunit (97 kDa) transmits a downstream signal by autophosphorylating tyrosine residues