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Whilst vitamin B12 side effects stomach-related are uncommon, some individuals experience mild gastrointestinal symptoms when taking supplements, particularly oral formulations

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Preclinical data show this additive-to-synergistic interaction: each pathway potentiates the other's pituitary response, producing larger GH pulses without proportionally increasing side effects

This phenomenon was further corroborated by elevated concentrations of glycolytic metabolites in the vastus lateralis muscle (74)

Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, et al