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This suggests that levels of free heme alone are not sufficient to immediately change the oxidative state of the parasite, although it is recognised that chemical inhibition of cysteine proteases may have additional impacts on the parasite, and does not perfectly mimic the heme depletion caused by K13-mediated alteration of hemoglobin uptake

Chapter 12

Richardson DR, Lok HC (2008) The nitric oxide-iron interplay in mammalian cells: transport and storage of dinitrosyl iron complexes

Katrina Wilhelm, ND is a board-certified naturopathic physician with a passion for functional medicine