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They electrically stimulated the intralaminar thalamic area of rabbits to induce sleep, collected the cerebral venous blood via extracorporeal dialysis, and fractionated the dialysate hunting for the substance responsible

Capillary filtration in the lower limbs was also significantly lower in supplemented subjects

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doi: 10.1089/thy.2007.0040 52 NordioMBascianiS