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10.1186/s40168-020-00914-w Microbiome 31 DalileB.Van OudenhoveL.VervlietB.VerbekeK

When these complexes are damaged by lipid peroxidation (the oxidative degradation of lipids in the mitochondrial membrane), ATP production grinds to a halt

Reactive oxygen species and oxidative stress

Toxicological findings consistently indicate size- and shape-dependent uptake and effects: smaller particles exhibit greater cellular internalisation, reactivity, and biodistribution, with predominant oxidative, inflammatory, metabolic, and genotoxic responses, whereas larger microplastics more often provoke mechanical irritation