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For example, individuals with Lebers disease, a rare genetic disorder, may be at risk of optic nerve damage from B12 injections

In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

This prevents cellular damage (like hemolysis) and discomfort

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