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The five-year data shows peak results at year one followed by gradual decline, suggesting a ceiling effect where continued use maintains rather than improves hair density

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Anti-MuSK antibodies are of the IgG4 subclass, which is less potent in immune activation and largely circulate with monovalent bispecificity because of a spontaneous Fab arm exchange but may still block the effects of its target [146]

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Theoretical concerns about growth factor modulation include potential interactions with cancer biology, though unsubstantiated

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