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Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

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They do not only regulate contraction of pericytes in response to neuronal activity, but are also able to induce the barrier-like phenotype of endothelial cells [32]