These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules
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Li, Z., Wang, X., Teng, D., Mao, R., Hao, Y., Yang, N., et al., Eur
Liver biopsy shows mild interface hepatitis and plasma cell infiltration of the hepatic parenchyma
2017, Tenchov et al 2024) which can reduce an individuals quality of life and lead to complications that overburden the healthcare system (Aina et al 2021)