All animal experiments were approved by the Institutional Animal Care and Use Committee of the CULAC, Chulalongkorn University, Bangkok, Thailand (Protocol number 2173003, Approval date: March 12, 2021)
The only exception was the conventional Neuromax B12 formulation, which led to significant changes in certain renal function parameters, such as serum levels of sodium, potassium, chloride, and bicarbonate, as well as in some hematological parameters, including the relative abundance of monocytes and basophils
Research shows the peptide upregulates cytoprotective factors such as heme oxygenase-1 and heat shock proteins, preserving mitochondrial function and reducing oxidative damage
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We found that melatonin increased GSH levels in human ILC2s whilst concurrently reducing their effector function