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A prolonged increase in intracranial pressure above mean arterial pressure may signify brain death and generally is a contraindication to liver transplant

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The second is the evidence gap : because the blend has never been trialed as a fixed product, every dose, schedule and timeline here is inference from the two component literatures, not a proven blend outcome

Metronidazole is no longer recommended, even in mild cases, owing to high rates of treatment failure and adverse effects