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In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

J Acquir Immune Defic Syndr Hum Retrovirol 1995

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Stephen Sinatra suggests you avoid mixing with grapefruit juice to ensure that you don't experience an adverse medication interaction