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Another observation from studies on murine models exposed to catabolic agents revealed a reduction in the excretion of N-methylhistidine, a marker of muscle protein degradation, which was notably more pronounced with IGF-1 LR3potentially three times greater than with IGF-I

Park et al reported that the target of statins in improving ED lies in antioxidation and inhibition of the RhoA/ROCK signaling pathway [178]