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First, side effects are clearly dose-dependent, increasing as the dose goes up

Stimulation of mu-opioid receptor (MOR) suppresses the inhibitory effect of GABA interneurons on DA neurons in the VTA

In line with these findings, a study group found phosphorylated SN deposits in proximal peripheral nerves of PD patients with small nerve fiber PN compared to atypical parkinsonism and healthy controls, with no significant differences between LDopa exposure or Vit B12 deficiency (Donadio et al

Mistake 5: Inaccurate Dosing Make sure you've drawn the correct amount