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Ltd., Tokyo, Japan), inddH2O (Millipore), and 0.1% formic acid in acetonitrile (ThermoFisher Scientific, USA) or 5.0 mM ammonium formate (Sigma) in ddH2O and acetonitrile at a flow rate of 0.25 mL/min

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In contrast, increased status of cellular H 2 O 2 (or exogenous H 2 O 2 ) can increase Pro level by modulating the ex-novo synthesis of Pro (Matysik et al., via GSH reductase (Anjum et al., 2012)