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Activation of sirtuins: Particularly SIRT1 and SIRT3, which are NAD+-dependent deacetylases involved in metabolic regulation and stress resistance 42

Phenylbutyrate is an HDAC inhibitor (similar action to butyrate from microbes) and TUDCA is a bile acid that can modulate gut microbiota composition as well as reduce ER stress in neurons [225]

Stacked Protocol (Ipamorelin + CJC-1295) Dose: 0.2 0.3 mg Ipamorelin + 0.1 mg CJC-1295 (= 46 clicks) Duration: 8 12 weeks Frequency: 1 2 daily Cycle Interval: 4 weeks off before repeating Goal / Description: Synergistic GHRH + GHRP combination studied for amplified GH pulse and IGF-1 response