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Abbreviations 6-OHDA: 6-Hydroxydopamine BAC: Bacterial artificial chromosome BBB: Bloodbrain barrier CAMs: Capillary-associated microglia CAT: Cationic amino acid transporter CNS: Central nervous system EAAT: Excitatory amino acid transporter FITC: Fluorescein isothiocyanate dextran FUS: Focused ultrasound Glut1: Glucose transporter-1 ICAM-1: Intercellular adhesion molecule-1 ICD: Intracellular domain IL: Interleukin iPSCs: Induced pluripotent stem cells LAT: L-type amino acid transporter LPS: Lipopolysaccharide LRP-1: Low-density lipoprotein receptor related protein-1 MCT: Monocarboxylate transporter MMP: Matrix-metalloprotease MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine PD: Parkinsons disease PFF: Preformed-fibrils P-gp: P-glycoprotein PPARy: Proliferator activated receptor pS129-Syn: -Synuclein phosphorylated at serine 129 RAGE: Receptor for advanced glycation end products SNCA: -Synuclein TfR: Transferrin receptor TNF: Tumor necrosis factor UDPRS: Unified Parkinsons disease rating scale VCAM-1: Vascular adhesion molecule-1 VEGF: Vascular endothelial growth factor References Takata F, Nakagawa S, Matsumoto J, Dohgu S
The biosynthesis of S-adenosylmethionine during homocysteine metabolism from methionine further activates DNA methyltransferases, leading to alterations in the DNA methylation status of various genes implicated in mitochondrial homeostasis [63]
doi:10.3390/biology10111165
