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The Applying ANN inference (ANNi) model, trained on human muscle transcriptomes, uncovered aging regulators including CHAD, ZDBF2, USP54, and JAK2, as well as exercise-responsive genes such as SCFD1 , KDM5D , EIF4A2 , and NIPAL3 , modeling directed regulatory interactions that prioritize candidate intervention targets while recognizing that definitive causality requires validation through orthogonal perturbation

Drugging IGF-1R in cancer: New insights and emerging opportunities

A recent systematic review and meta-analysis highlighted the high global prevalence of diabetic foot ulceration among DPN patients, emphasizing the critical need for early detection and comprehensive management strategies to prevent severe outcomes

DOI: 10.1074/jbc.273.19.11401 16