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Mitochondrial dysfunction in age-related metabolic disorders

Free Radic Biol Med 63:5164 Schrammel A, Gorren AC, Schmidt K, Pfeiffer S, Mayer B (2003) S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-)

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These changes were mirrored by changes in the lung (Figure 5A) and liver (Figure 5B) tissue GCL activity which is a good indicator of a tissue's capacity to maintain GSH levels

Additionally, oral supplements can cause mild stomach discomfort or prove less effective due to inadequate intestinal absorption