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The Journal of the International Society of Sports Nutrition found that chronic consumption of a multi-ingredient pre-workout combined with resistance training appears to augment beneficial changes in body composition through increased lean mass accretion . (4) Additionally, an example blend of ingredients that includes caffeine, creatine, beta-alanine, [and] amino acids may elicit a synergistic effect on acute exercise performance and subsequent training adaptations compared to single ingredients alone . In Laymans terms, your training in the gym is likely to improve if you consume a multi-ingredient pre-workout beforehand rather than taking only one ingredient