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The most common short-term effects were skin rash or itchy skin, inflammation of the thyroid (thyroiditis) or low thyroid hormones (hypothyroidism), and joint pain

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(Neuropsychobiology 1992) documented a 59% improvement in sleep duration (+130 minutes) in chronic insomniac patients

A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]