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Indeed, conducting large controlled clinical trials using AOXs supplementation is mandatory to evaluate their influence on ICSI outcome

[10] studied the oxazolone derivative GANRA-5 (a known free radical scavenger) on human lung fibroblasts

Despite these higher numbers aged macrophages are less active, with altered expression and function of TLRs [148], decreased cytokine and growth factor production [149] and reduced phagocytic activity compared to macrophages from younger counterparts [150]

Therefore, ongoing efforts focus on developing nanotechnology-based delivery systems and combination therapies to overcome these limitations and enhance the therapeutic efficacy of antioxidants [246,247,248]

European Neuropsychopharmacology, 19(S9), S681S682