The enhanced production of superoxide would allow its reaction with nitric oxide (NO) within the mitochondria producing the reactive radical peroxynitrite (ONOO ), which can nitrate protein tyrosine residues and compromise their function [40] (Figure 1)
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In a study utilizing scRNA-seq data sets, the abnormal trends of genes related to ferroptosis and necroptosis were analyzed in several representative autoimmune diseases (psoriasis, atopic dermatitis, vitiligo, multiple sclerosis, and systemic sclerosis-associated interstitial lung disease)
