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Conventional therapies fall short in high-risk populations (e.g., obesity and renal impairment) due to toxicity and adherence limitations

Sigma-1 receptors can also exert antidepressant effects through modulating serotonin 5-HT 1A function or modulation of the endoplasmic reticulum stress response, thus facilitating BDNF expression [130]

Glutathione peroxidase (GPX) catalyzes the reduction of an organic peroxide (ROOH), oxidizing reduced glutathione (GSH) to form disulfde glutathione (GSSG)

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Free radicals are harmful compounds that build up in your body over time