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It seems that ZIP8 plays a crucial role in inflammation

Gomaa et al., 2019)

doi: 10.1038/ni.3439 112 NakajimaHKunimotoH

To measure PIP 3 , FoB were stimulated with 5 g/mL anti-IgM (Jackson Immunoresearch 715-006-020) for the indicated time points, then fixed in 2% FA and permeabilized with 0.1% saponin