Recent studies have revealed that Damage-Associated Molecular Patterns (DAMPs) (e.g., High Mobility Group Box 1 (HMGB1) via TLR4/Myeloid Differentiation Primary Response 88 (MyD88) signaling and mtDNA through the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway) released by apoptotic bodies polarize Kupffer cells towards the M1 phenotype, promoting the secretion of inflammatory cytokines such as IL-1 and IL-18 , thus activating the NACHT , LRR and PYD domains-containing protein 3 (NLRP3) inflammasome and producing a second hit effect 51
Musculoskeletal and soft tissue healing depend on coordinated vascular support with resolution of inflammatory stress
Effects of LDL enriched with different dietary fatty acids on cholesteryl ester accumulation and turnover in THP-1 macrophages
doi: 10.1016/j.cmet.2018.06.004 149
Watermelon seeds, which can be eaten raw or dried, are rich in magnesium which Derocha explains plays a key role in energy production, nerve function, DNA and protein synthesis, as well as blood pressure regulation
