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10.1519/JSC.0000000000001437 70 NaseemK

The IGF-1/IGF-1R axis can also induce phosphorylation of ER through ribosomal S6 kinase 1 (S6K1), downstream of the PI3K/AKT/mTOR pathway which results in the upregulation of IGF-1, IGF-1R and other ER target genes (Kim et al., 2007)

doi: 10.3390/brainsci11020142 34

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This widespread expression reflects the vitamin's diverse roles in reproduction from regulating ovarian steroidogenesis (sex hormone production) to modulating the immune environment of the uterus that governs implantation