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Human data on BPC-157 remains limited but is emerging: Chronic knee pain (2021 retrospective): In a small retrospective series of 12 patients with unspecified chronic knee pain who received a single intra-articular injection, 7 of 12 reported pain relief lasting more than 6 months

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Safety concerns included uncharacterized immunogenicity (the risk that injected peptides trigger immune reactions), inadequate impurity and endotoxin testing in available raw material, the unresolved free base versus acetate salt form distinction, and, for BPC-157 specifically, an angiogenesis mechanism that raises theoretical cancer-risk concerns for certain patient populations

PMID: 10458244

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