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They operate through specific, well-documented pathways

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As for individuals misusing GH for recreational and athletic performance-enhancing purposes, GH, IGF-I and insulin levels are increased suggesting that insulin sensitivity is worsened and iatrogenic acromegaly is induced, especially if used long-term

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A more complete toxicological profile requires future investigations incorporating time-course histopathology (e.g., H&E staining of liver tissue), analysis of tissue-specific iron distribution, and measurement of systemic acute-phase response markers