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Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists

The same milligrams read as a quiet, mostly-metabolic experience in one person and an appetite-and-heart-rate experience in another

CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis

Research identified 127 genes whose expression was significantly altered in COPD patients, with more severe emphysema symptoms correlating with degree of gene expression changes

Notably, in a recent chemical screen in the ferroptosis-sensitive HT-1080 N fibrosarcoma cells, seven out of eight PI3K/mTOR inhibitors suppressed the ferroptosis-inducing activity of erastin and sorafenib, but not the covalent GPX4 inhibitor, ML162 19