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For instance, TiO 2 alone was able to enrich 711 phosphopeptides from 100 g of HEK 293T cell lysate digest and 1,403 phosphopeptides from 100 g of SH-SY5Y cell lysate digest

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Escalate: Increase by 2.5 mg every 4 weeks as tolerated

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Not a dealbreaker, but a step behind #1-3 on this list